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I really think we're dealing with some very complicated biochemistry here.

I really think we're dealing with some very complicated biochemistry here. I have never seen a single psych drug, the PI sheet for which did not begin, "The exact mechanism of action is unknown" (or words to that effect). And that includes very old drugs like Lithium. Obviously, these drugs can provide relief for people suffering from various kinds of mental disorders. Most of them target serotonin, norepinephrine, dopamine, and a laundry list of receptors. Yet it still amazes me that no one can seem to draw a clear line between these chemical interventions and relief from symptoms. Given all that, every piece evidence becomes potentially significant. But it also means a long, long slog through inferential statistics, patient self-reports, placebo effects, and targeted studies like this one that may fail to account for a thousand other factors. I'm not a biochemist, but I think I would find this work both fascinating and very frustrating.

Posted by sramsay on Jun 19, 2015, 2:57 PM

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I really think we're dealing with some very complicated biochemistry here.

sramsayJun 19, 2015, 2:57 PM

I really think we're dealing with some very complicated biochemistry here. I have never seen a single psych drug, the PI sheet for which did not begin, "The exact mechanism of action is unknown" (or words to that effect). And that includes very old drugs like Lithium. Obviously, these drugs can provide relief for people suffering from various kinds of mental disorders. Most of them target serotonin, norepinephrine, dopamine, and a laundry list of receptors. Yet it still amazes me that no one can seem to draw a clear line between these chemical interventions and relief from symptoms. Given all that, every piece evidence becomes potentially significant. But it also means a long, long slog through inferential statistics, patient self-reports, placebo effects, and targeted studies like this one that may fail to account for a thousand other factors. I'm not a biochemist, but I think I would find this work both fascinating and very frustrating.

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