I am not sure the title is correct: * The word "hormone" does not appear in the article * In the WP article about "chaperome" there is ...
I am not sure the title is correct: * The word "hormone" does not appear in the article * In the WP article about "chaperome" there is no mention of "hormone". My understanding is that the article is about a concept a bit similar, but more operational than the concept of protein networks. And it is about networks of chaperomes, which are themself sets of chaperones. Chaperones are very powerful proteins that shape the proteins produced in the cell nucleus, in order to give them some specific function. Protein networks are very conceptual entities, that for example could hardly be tested with some reagent. Here on contrary they could test for existence of epichaperomes. The authors found that Alzheimer disease could be thought as a disease of epichaperomes. To me it makes sense, as most neurodegenerative diseases are known to be proteopathies: Diseases linked to misshaped and mislocated proteins. They hypothesized that epichaperomes reagents will enable easy diagnostic of such diseases. There is an unmet need for neurodegenerative diseases biomarkers, as currently they can only be detected when it is too late to make a clinical intervention, and when even the classification of a patient in some disease type is difficult leading diagnostic by exclusion, which is only way to say: I do not know what disease makes patient ill . Trusted biomarkers in neurodegenerative diseases would change life of doctors and patients.
Posted by JPLeRouzic on Jan 20, 2020, 5:42 AM
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Prevalence of the disease - if it only impacts 1/100 million, going to be hard to ever find sufficient patient population to test an...
I am not sure the title is correct: * The word "hormone" does not appear in the article * In the WP article about "chaperome" there is ...
I am not sure the title is correct: * The word "hormone" does not appear in the article * In the WP article about "chaperome" there is ...
I am not sure the title is correct: * The word "hormone" does not appear in the article * In the WP article about "chaperome" there is no mention of "hormone". My understanding is that the article is about a concept a bit similar, but more operational than the concept of protein networks. And it is about networks of chaperomes, which are themself sets of chaperones. Chaperones are very powerful proteins that shape the proteins produced in the cell nucleus, in order to give them some specific function. Protein networks are very conceptual entities, that for example could hardly be tested with some reagent. Here on contrary they could test for existence of epichaperomes. The authors found that Alzheimer disease could be thought as a disease of epichaperomes. To me it makes sense, as most neurodegenerative diseases are known to be proteopathies: Diseases linked to misshaped and mislocated proteins. They hypothesized that epichaperomes reagents will enable easy diagnostic of such diseases. There is an unmet need for neurodegenerative diseases biomarkers, as currently they can only be detected when it is too late to make a clinical intervention, and when even the classification of a patient in some disease type is difficult leading diagnostic by exclusion, which is only way to say: I do not know what disease makes patient ill . Trusted biomarkers in neurodegenerative diseases would change life of doctors and patients.
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