Given the unmet need for anything to treat dementia, anything that really has a positive effect is basically like printing money.
Given the unmet need for anything to treat dementia, anything that really has a positive effect is basically like printing money. It would not be hidden, it would be out there until the patents ran out. And the amyloid situation is a word of warning to anybody thinking they could really speed up drug discovery. The researchers had a model. They created various compounds that were effective vs this model. These compounds were active in vivo vs the model target and safe to deliver. Problem was, they didn’t actually do anything vs dementia. The human body isn’t really well understood. There are unknown mechanisms and interactions that appear at unexpected often undesirable times. There’s things that only show up in human testing, after models and animal testing shows no problems. And as in this case, the disease reveals it’s not really understood. Companies have burned through billions chasing this as the upside is damn well infinite.
Posted by jleyank on Oct 11, 2025, 7:14 PM
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The biggest problem with MOND is that it was hand-crafted with additional parameters simply to fit the data.
(My comment is about detached houses).
The biggest problem with this is that I can't run my company's own internal benchmarks against this API, because they will be trained int...
> steer Claude away from over-engineering parts of the system in response to hypothetical concerns.
Why is there no comparison with FLUX 3 Image?
> our Git monorepo was developing an annoying problem Sentences like this are so common from people using monorepos that I am convinced ...
Why is there no contact form?
The biggest problem with plugging a generator into an outlet is you need a double ended cord.
Given the unmet need for anything to treat dementia, anything that really has a positive effect is basically like printing money.
Given the unmet need for anything to treat dementia, anything that really has a positive effect is basically like printing money. It would not be hidden, it would be out there until the patents ran out. And the amyloid situation is a word of warning to anybody thinking they could really speed up drug discovery. The researchers had a model. They created various compounds that were effective vs this model. These compounds were active in vivo vs the model target and safe to deliver. Problem was, they didn’t actually do anything vs dementia. The human body isn’t really well understood. There are unknown mechanisms and interactions that appear at unexpected often undesirable times. There’s things that only show up in human testing, after models and animal testing shows no problems. And as in this case, the disease reveals it’s not really understood. Companies have burned through billions chasing this as the upside is damn well infinite.
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