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Their experimental approach was interesting and hopefully will lead to more discoveries.

Their experimental approach was interesting and hopefully will lead to more discoveries. I feel like this drug is already being overhyped however. It doesn't work for gram negative bacteria, which are responsible for most of the serious and scary multi drug resistant infections. Also, assuming it doesn't have weird toxicity in people, or unfavourable pharmacokinetics, the author's suggestion that we should give it to everyone is a bit cute, given that it will almost certainly cost north of $200 per day if it gets to market... Peptide antibiotics can have some issues. A recent new peptide antibiotic called Daptomycin [1] can't be used for pneumonia for example, because it is inhibited by pulmonary surfactant. [1] http://en.m.wikipedia.org/wiki/Daptomycin

Posted by Gatsky on Jan 8, 2015, 12:45 AM

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Their experimental approach was interesting and hopefully will lead to more discoveries.

GatskyJan 8, 2015, 12:45 AM

Their experimental approach was interesting and hopefully will lead to more discoveries. I feel like this drug is already being overhyped however. It doesn't work for gram negative bacteria, which are responsible for most of the serious and scary multi drug resistant infections. Also, assuming it doesn't have weird toxicity in people, or unfavourable pharmacokinetics, the author's suggestion that we should give it to everyone is a bit cute, given that it will almost certainly cost north of $200 per day if it gets to market... Peptide antibiotics can have some issues. A recent new peptide antibiotic called Daptomycin [1] can't be used for pneumonia for example, because it is inhibited by pulmonary surfactant. [1] http://en.m.wikipedia.org/wiki/Daptomycin

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