But turning an off-label use into an on-label one to promote it has its own nasty consequences, even if the drug is proven to work for th...
But turning an off-label use into an on-label one to promote it has its own nasty consequences, even if the drug is proven to work for the new indication (or whatever). Consider Lucentis vs Avastin. Ophthalmologists were using Avastin off-label for wet AMD. Genentech was making a huge multifaceted effort to discourage off-label use because they had sunk a bunch of effort/$ into the order-of-magnitude-more-expensive Lucentis for not much of an improvement. Similar situation and different ending with Lumigan (glaucoma/ocular hypertension eyedrops) vs Latisse (eyelash enhancer), where Latisse's patent (afaik) was thrown out because Allergan was trying to patent a known major side effect of Lumigan. I'm not a fan of misleading promotions of off-label uses either, but I wish there was a middle ground still banning that that didn't also involve more patents and protection.
Posted by silencio on Nov 16, 2014, 6:38 AM
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Raise real-world problems, find people facing the same issue, and discuss solutions.9,000 issues0 comments
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Fake websites pretending to be legitimate websites in order to steal your passwords was considered a HUGE problem.
3.5 Flash was always too expensive for a "flash" model.
I don't think the realistic alternative here was “hire a team for a month and get a better semantic conversion” For a rewrite of this si...
I was hosting on a PC at home like 10 years ago.
I live in walking distance of all these things, and the farthest I’ve gotten my kid to do things alone is to walk to and from school (a w...
It was a long time ago, so I don't remember.
I still like to buy my cheap and esoteric Chinese stuff from Amazon.
My local area used to be great to find old used woodworking tools for cheap.
But turning an off-label use into an on-label one to promote it has its own nasty consequences, even if the drug is proven to work for th...
But turning an off-label use into an on-label one to promote it has its own nasty consequences, even if the drug is proven to work for the new indication (or whatever). Consider Lucentis vs Avastin. Ophthalmologists were using Avastin off-label for wet AMD. Genentech was making a huge multifaceted effort to discourage off-label use because they had sunk a bunch of effort/$ into the order-of-magnitude-more-expensive Lucentis for not much of an improvement. Similar situation and different ending with Lumigan (glaucoma/ocular hypertension eyedrops) vs Latisse (eyelash enhancer), where Latisse's patent (afaik) was thrown out because Allergan was trying to patent a known major side effect of Lumigan. I'm not a fan of misleading promotions of off-label uses either, but I wish there was a middle ground still banning that that didn't also involve more patents and protection.
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